Geometrical multi-scale modeling and computation of arterial hemodynamics: from basic theories to applications
Arterial hemodynamics is highly complex, spanning a wide range of fluid dynamics phenomena from system-level pulse wave propagation to flow patterns in local regions.In particular, arterial pressure wave has long been recognized to carry important information reflective of the functional status of the cardiovascular system.Accordingly, numerous studies have been dedicated to exploiting the clinical implications of arterial pressure wave.Under in vivo conditions, the characteristics of an arterial pressure wave are determined by various cardiovascular factors, which interact with each other, differ considerably among subjects and are subject to complicated changes under pathological conditions, making it extremely difficult to discriminate the specific contribution of an individual cardiovascular factor to a measured pressure wave.In this study, we proposed a geometrical multi-scale modeling method to construct a computational model capable of simulating arterial pressure wave and its interaction with systemic hemodynarnics based on a comprehensive representation of various cardiovascular properties.The model was firstly applied to investigate the changes in arterial pressure wave during normal aging, and subsequently coupled with a mechanical model of an oscillometry upper-arm cuff to yield a mathematical tool for exploring novel methods for noninvasively estimating aortic blood pressure.
Arterial hemodynamics Pressure wave Multi-scale modeling
LIANG Fu-you
School of Naval Architecture, Ocean and Civil Engineering, Shanghai Jiao Tong University, Shanghai, 200240
国内会议
江苏镇江
英文
88-98
2018-08-01（万方平台首次上网日期，不代表论文的发表时间）