Olanzapine for the treatment of acute symptoms of mental disorders induced by amphetamine-type stimulants: a randomized controlled trial with comparison of haloperidol
Introduction: This study aimed to compare olanzapine and haloperidol efficacies in the treatment of acute psychiatric symptoms due to amphetamine-type stimulants.Methods: The Zelen”s Ⅱ design method was used;124 patients with acute mental disorders due to amphetamine were randomly divided into olanzapine group(n=63) and haloperidol group(n=61).Then, a four-week open-label medical therapy was performed.Clinical Global Impression Scale Item 2 was employed to evaluate the onset time;meanwhile,Brief Psychiatric Rating Scale (BPRS) was used at baseline and at post-treatment weeks 1, 2 and 4.Moreover, adverse reactions during the treatment were recorded.Methods: Onset time in the olanzapine group was significantly earlier than in the haloperidol group;BPRS scores in the olanzapine group were significantly lower than haloperidol group values at 1 and 2 weeks of treatment.The overall effective rates had no statistically significant difference.Discussion: Short-term olanzapine and haloperidol treatments had equivalent efficacies in the treatment of acute symptoms of mental disorders due to amphetamine-type stimulants;however, olanzapine administration resulted in relatively earlier disease onset, with less adverse reactions.
Olanzapine Haloperidol Amphetamine-type stimulants Mental disorder
Xu Chen Xiaobin Xue Qiang Fan Yun Song Jiyou Tang Wei Yuan
Department of Substance Abuse, Shandong Mental Health Center, China Department of Substance Abuse, Qingdao Mental Health Center, Qingdao, China Department of Substance Abuse, Ningbo An Kang Hospital, Fenghua, China Department of Neurology,Qianfoshan Hospital Affiliated of Shandong University, Jinan, China
国内会议
2017全国药物滥用防治研讨会暨第十届内地及港澳地区药物滥用防治研讨会
香港
英文
232-236
2017-10-17（万方平台首次上网日期，不代表论文的发表时间）