Related to ”Is K-ras Gene Mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis”
Theras oncogene mutation is one of the commonly associated with colorectal cancer, especially the Kras mutation.However, the ras gene as a prognostic factor for patients with colorectal cancer remains unknown.With great interest we read the JiaoJiao Ren”spaper entitled ”Is K-ras Gene Mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis”, and two data in JiaoJiao Ren”s study, as existing serious error and affecting the subsequently subgroup analysis.We re-extracted the data from the two articles and obtained new HRs of 2.40 (95% CI, 1.09-5.29, p=0.03) and 1.49 (95%CI, 0.94-2.38, p=0.09), respectively, based on the two article”s Log-Rank p value.Finally, we got the pooled HRs of 1.04 (95% CI, 0.84-1.29, p=0.73) which indicated that K-ras gene mutations not to correlate with the prognosis of patients with colorectal cancers.
KRas prognostic colorectal p21
Peng Wang Yiyuang Wang Shuang Bai Yanling Hong Xinliang Zhou Julun Yang
Department of Pathology, Kunming General Hospital
国内会议
北京
英文
339-345
2016-12-02（万方平台首次上网日期，不代表论文的发表时间）