Diane-35 combinated with metformin attenuates carbohydrate and lipid metabolic index in polycystic ovary syndromepatients:a systematic review
AIM:To evaluate the effects of combined metformin and Diane-35 administration in polycystic ovary syndrome(PCOS)patients.METHODS:We searched MEDLINE),the Cochrane Central Register of Controlled Trials,PubMed and the Chinese National Knowledge In frastructure.Seven randomized control trials with a total of 347 PCOS patients were included.RESULTS:Seven randomized control trials with a total of 347 PCOS patients were included.Meta-analysis showed a significant effect of Diane-35 plus metformin on improving BMI in PCOS patients was observed when compared with Diane-35 alone(WMD=-1.01,95%CI”-1.56,-0.45”,Z=3.56,P=0.0004).Subgroup analysis of observational studies showed that 1)A significant effect of Diane-35 plus metformin on improving TC in PCOS patients was observed when compared with Diane-35 alone(WMD=-0.35,95%CI”-0.47,-0.24”,Z=5.87,P<0.00001.).2)A significant effect of Diane-35 plus metformin on improving TG in PCOS patients was observed when compared with Diane-35 alone(WMD=-0.18,95%CI”-0.33,-0.04”,Z=2.52,P=0.01.).3)A significant effect of Diane-35 plus metformin on improving LDL-C in PCOS patients was observed when compared with Diane-35 alone(SMD=-0.15,95%CI”-0.24,-0.06”,Z=4.31,P=0.0007.).4)A significant effect ofDiane-35 plus metformin on improving FBG in PCOS patients was observed when compared with Diane-35 alone(WMD=-0.50,95%CI”-0.68,-0.32”,Z=5.34,P<0.00001.).5)A significant effect of Diane-35 plus metformin on improving FINS in PCOS patients was observed when compared with Diane-35 alone(and SMD=-1.65,95%CI”-2.15,-1.15”,Z=6.46,P<0.00001.)6)A significant effect of Diane-35 plus metformin on improving HOMA-IR in PCOS patients was observed when compared with Diane-35 alone(SMD=-1.21,95%CI”-1.55,-0.88”,Z=7.21,P<0.00001.).Conclusion(s):Diane-35plus metformin will be helpful for improving metabolic symptoms in polycystic ovary syndrome patients.
Combined therapy Diane-35 Metformin Polycystic Ovary Syndrome
Chenglai Xia Jinman Chen Jie Yang Ruihong Chen Shaofen Liang Guohong Xiao
Department of Pharmacy,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou,51015 Guangdong Provincial Key Laboratory of Reproductive Medicine,Guangzhou510150,China;Department of Rep Guangdong Provincial Key Laboratory of Reproductive Medicine,Guangzhou510150,China;Guangdong Provinc
国内会议
西安
英文
1109-1121
2017-11-04（万方平台首次上网日期，不代表论文的发表时间）