Determination of nine volatile N-nitrosamines in tobacco and smokeless tobacco products by dispersive solid-phase extraction with gas chromatography and tandem mass spectrometry
A method was developed for the determination of nine volatile N-nitrosamines in tobacco and smokeless tobacco products.The targets are N-nitrosodimethylamine,Nnitrosopyrrolidine,N-nitrosopiperidine,N-nitrosomorpholine,N-nitrosoethylmethylamine,N-nitrosodiethylamine,N-nitrosodipropylamine,N-nitrosobuylmethylmine,and Nnitrosodibutylamine.The samples were treated by dispersive solid-phase extraction using 1 g of primary secondary amine and 0.5 g of carbon and then analyzed by gas chromatography with tandem mass spectrometry with an electron impact ion source.The recoveries for the targets ranged from 84 to 118%,with <16%relative standard deviations at three spiking levels of 0.5,1.25,and 2.5 ng/g.The limits of detection ranged from 0.03 to 0.15 ng/g.With the use of the proposed method,we detected the presence of six nitrosamines in the range of 0.4–30.7 ng/g.The study demonstrated that the method could be used as a rapid,convenient,and high-throughput method for N-nitrosamines analysis in tobacco matrix.
Dispersive solid-phase extraction Gas chromatography with tandem mass spectrometry N-nitrosamines Tobacco
Fang Lv Junwei Guo Fei Yu Tingting Zhang Shimin Zhang Huapeng Cui Xianjun Liu Li Chen Leiyu Liu Shaofeng Liu Fuwei Xie
Zhengzhou Tobacco Research Institute of CNTC,Zhengzhou,China China Tobacco Zhejiang Industrial Co.,Ltd.,Hangzhou,China Gold leaf Manufacturing Center of China Tobacco Henan Industrial Co.,Ltd.,Zhengzhou,China Technique Center of Tobacco Production,PingDingshan Tobacco Company of Henan Tobacco Monopoly Bureau
国内会议
北京
英文
2123-2128
2017-11-01（万方平台首次上网日期，不代表论文的发表时间）