Safety assessment of xylan by an oral acute toxicity study in mice and a 90-day feeding study in rats
Xylans are present naturally in various plants and have important use in nutrition,food,novel material and biotechnology; however,data regarding their systemic toxicity and safety evaluation is still limited.This study investigated the potential toxicity of xylan from sugarcane bagasse by an acute oral toxicity study in mice and a subchronic toxicity study in rats.In acute toxicity study,xylan was orally administered to mice three times a day at a total dose of 1.5 g kg-1 body weight(bw).No mortality or signs of toxicity was observed throughout the acute toxicity study.The Maximum Tolerated Dose of xylan for both sexes of mice was over 1.5 kg bw day-1.In the subchronic toxicity study,a total of 80 male and female rats were fed with diets containing 10%,5%,2.5%and 0%(control)xylan for 90 days.A toxicological assessment was performed including mortality,body and organ weights,food consumption,blood biochemistry,hematology,urinalysis,gross necropsy and histopathological examinations.There were no signs of toxicity and treatment-related changes in rats treated with xylan.The no-observed-adverse-effect level of xylan was 9.0 g kg-1 bw for males and 10.6 g kg-1 bw for females of rats under this experimental conditions.
xylan acute toxicity subchronic toxicity feeding study
Guangqiu Qin Pingjing Wen Yanwu Wang Lujuan Zhang Huili Liang Huiyan Qin Song Tang Pengzhao
Institute of Toxicology,Guangxi Center for Disease Prevention and Control,Nanning 530028,China School of Environment and Sustainability,University of Saskatchewan,Saskatoon,SK,S7N5B3,Canada
国内会议
海口
英文
14-23
2017-12-06（万方平台首次上网日期，不代表论文的发表时间）