Diagnosis value of aberrantly expressed microRNA profiles in lung squamous cell carcinoma:a study based on The Cancer Genome Atlas
”Objective”Lung cancer is considered as one of the most frequent and deadly cancers with high mortality all around the world.It is critical to find new biomarkers for early diagnosis of lung cancer,especially the lung squamous cell carcinoma(LUSC).The Cancer Genome Atlas(TCGA),is a database which provides both cancer and clinical information.This study is a comprehensive analysis of a novel diagnostic biomarker for LUSC,based on TCGA.”Methods”The present study investigated LUSC-specific key microRNAs(miRNAs)from large-scale samples in TCCA.Expression profiles of miRNAs with related clinical information of 332 LUSC patients were got from TCGA.Most remarkable mutative miRNAs were identified between tumor and normal samples.”Results”Totally 42 LUSC-specific intersection miRNAs(fold change>2,P<0.05)were obtained by comparing in Level 3,among them six miRNAs were found to be aberrantly expressed concerning clinical features(gender,lymphatic metastasis,patient outcome assessment).Then five miRNAs were correlated with overall survival(log-rank P<0.05).Also,the diagnostic value of these above five miRNAs was determined by areas under receiver operating characteristic curves(ROC).Finally,577 interaction mRNAs as the targets of 42 LUSC-specific intersection miRNAs were selected for further bioinformatics analysis.”Conclusion”This study indicates that the novel microRNA expression signature may be a useful biomarker of the diagnosis for LUSC patients,based on bioinformatics analysis.
microRNA TCGA LUSC diagnostic biomarker
YANG Sheng SUI Jing LIANG Ge-yu
Key Laboratory of Environmental Medicine Engineering,Ministry of Education,School of public Health,Southeast University,Nanjing,Jiangsu,P.R China
国内会议
上海
英文
237-244
2017-11-05（万方平台首次上网日期，不代表论文的发表时间）