O-苄基羟胺与丙酸乙酯经缩合、Pd催化C(sp2)-H键芳基化和苄基C-O键溶剂解反应序列合成2-芳基苄基乙酸酯
The straightforward synthesis of 2-arylbenzyl acetates has been developed via a reaction sequence of condensation of O-benzylhydroxylamines with ethyl pyruvate,palladium(Ⅱ)/(Ⅳ)-catalyzed ortho-C(sp2)-H bond arylation with aryl iodides directed by ketoxime ester group,and benzylic C-O bond nucleophilic solvolysis.As for electron-deficient aryl iodide coupling partners,the preinstalled pyruvate ketoximesare needed for achieving target products.A palladacycle intermediate is confirmed by X-ray crystallography to reveal the N, O-bidentate chelating pattern inpivotal C(sp2)-H bond actmation.
2-芳基苄基乙酸酯 合成工艺 O-苄基羟胺 丙酸乙酯 缩合反应 C(sp2)-H键 芳基化反应 苄基C-O键 亲核反应
邵玲艳 邢立浩 郭瑛 虞艳坤 冀亚飞
华东理工大学药学院,上海 200237
国内会议
中国药学会制药工程专业委员会2017年学术年会暨药包材与药品关联审评审批研讨会
合肥
中文
1-10
2017-10-21（万方平台首次上网日期，不代表论文的发表时间）