Growth factors changes in cerebrospinal fluid of children with mental retardation before and after neural precursor cell transplantation
Objective:To investigate cytokine changes in cerebrospinal fluid(CSF)of children with mental retardation(MR)before and after neural precursor cell transplantation(NPCT),in an attempt to provide experimental clues for the clinical treatment of MR with NPCT.Methods:The study comprised 28 MR children who received twice NPCT in our hospital.CSF was collected at both NPCT to assess growth factors by ELISA.In addition,the content of insulin-like growth factor 1(IGF-1)in CSF was assayed to determine possible correlations between IGF-1 changes and the short-term therapeutic effect of NPCT.Results:Of all the growth factors detected in CSF,only IGF-1 was increased significantly after NPCT(P<0.05).Fifteen of the twenty-eight MR children achieved short-term therapeutic efficacy,whereby the content of IGF-1 after NPCT was significantly higher than that before NPCT(P<0.05).There was no difference in IGF-1 content in the remaining 13 MR children without short-term therapeutic effect(P=0.657).There was significant difference in IGF-change between the two groups of patients(P<0.05).Conclusion:IGF-1 may be one of the mechanisms contributing to the therapeutic effect of NPCT.
mental retardation neural precursor cell transplantation insulin-like growth factor 1 growth factors
Hui Yang Yinxiang Yang Suqing Qu Zhaoyan Wang Wei Lu Fang Liu Weipeng Liu Qian Wang Hari Sharma Zuo Luan
Department of Pediatrics,Navy General Hospital,Beijing,P.R.China
国内会议
西安
英文
29-49
2017-07-07（万方平台首次上网日期，不代表论文的发表时间）