Genomic alterations and survival in young patients aged under 40 years with completely resected non-small cell lung cancer
Young patients are rarely diagnosed as non-small cell lung cancer(NSCLC).Little is known for its genomic alterations and survival.This retrospective study was conducted for evaluating the genomic alterations,treatment and prognosis of young patients aged under 40 years from a cohort of 640 subjects.All patients were examined for EGFR,KRAS,NRAS,PIK3CA,BRAF,HER2 mutations and ALK,ROS1 and RET fusion genes based on reverse transcription polymerase chain reaction(PCR).Totally,54 were aged under 40 years.And 358 of 640 patients harbored genomic alterations with a frequency of 55.9%.The frequencies of genomic alterations in younger(≤40 years)and elder(>40 years)were 68.5%and 54.8%respectively(P=0.05).The frequency difference between younger and elder existed in fusion genes(22.2%vs.4.1%,P<0.001),but not mutated genes(46.3%vs.45.6%,P=0.92).There was a general trend of shorter recurrence-free survival(35.2 vs.43.8 months,P=0.050)while no overall survival(50.2 vs 51.4 months,P=0.112)difference existed between younger and elder.Thus younger age of NSCLC has a rising trend of harboring targeted genes and it is mainly caused by different fusion genes.And worse overall survival existed in younger patients.
genomic alterations non-small cell lung cancer age survival
国内会议
合肥
英文
1-10
2017-06-15（万方平台首次上网日期，不代表论文的发表时间）