Factors Influencing Survival of Patients with Pancreatic Adenocarcinoma and Synchronous Liver Metastases Receiving Palliative Care
Background and Aims:Patients with pancreatic ductal adenocarcinoma and synchronous liver metastases(PACLM)have an extremely limited life expectancy.We performed a single-center analysis to explore the clinical results and prognostic factors of patients with PACLM receiving palliative care.Methods:We retrospectively reviewed 189 patients undergoing palliative care at Tianjin Medical University Cancer Hospital over a 15-year period.Clinical characteristics,survival condition,and factors associated with survival were analyzed.Treatment methods included palliative bypass surgery,percutaneous transhepatic cholangiodrainage,drug analgesia,symptomatic treatment,and other nutritional or supportive measures.Results:The overall survival(OS)was 3.6 months for all patients.Multivariate analysis for clinical features showed that Karnofsky performance score(KPS),ascites,cigarette smoking,primary tumor size,and lactate dehydrogenase(LDH)were prognostic variables with statistical significance(P<0.05).The patients were classified into three groups of patients according to how many of these 5 risk factors were present:0-1,2,or 3-5 risk factors.The median OS of the 3 groups of patients were 5.0,3.3,and 2.5 months,respectively,with a notable statistical significance(P<0.0001).Conclusions:KPS<80,ascites,cigarette smoking,primary tumor size≥5cm,and LDH≥250U/L are effective predictive factors of poor prognosis for patients with PACLM.The stratification of treatment outcome groups based on these factors facilitates evaluation of individual prognosis and can guide clinical decisions.
pancreatic adenocarcinoma liver metastases palliative care prognosis survival analysis
Huaqiang Ouyang Weidong Ma Fang Liu Zhensong Yue Minghui Fang Manman Quan Zhanyu Pan
National Clinical Research Center of Cancer,Key Laboratory of Cancer Prevention and Therapy,West Hua National Clinical Research Center of Cancer,Key Laboratory of Cancer Prevention and Therapy,West Hua National Clinical Research Center of Cancer,Key Laboratory of Cancer Prevention and Therapy,West Hua
国内会议
合肥
英文
1-26
2017-06-15（万方平台首次上网日期，不代表论文的发表时间）