Successful treatment of advanced pancreatic liposarcoma with apatinib:a case report and literature review
Pancreatic liposarcoma is a malignant tumor originated from the pancreas mesenchymal tissue and mostly presented in skin,subcutaneous,periosteum,and long bone on both sides.Both conventional chemotherapy and radiotherapy have limited efficacy and poor prognosis for advanced pancreatic liposarcoma.Here,we reported a case of advanced pancreatic liposarcoma and reviewed the literature specific for liposarcoma of the pancreas and discuss the emerging options of treatment.The patient was treated with apatinib and a cross-line rescue therapy combined with paclitaxel after progressive disease.The therapeutic effect of the combination regimen has been evaluated.Apatinib is an oral tyrosine kinase inhibitor targeting the intracellular domain of vascular endothelial growth factor receptor-2(VEGFR-2),which has dual effects of anti-angiogenesis and anti-tumor cell proliferation.To our knowledge,this is the first case to report the successful use of apatinib for advanced pancreatic liposarcoma.
Liposarcoma Pancreatic cancer Apatinib Paclitaxel Prognosis
Tao Han Yuting Luan Zhendong Zheng
Department of Oncology,Cancer center of People”s Liberation Army,General Hospital of Shenyang Military Region,Shenyang 110840,P.R.China
国内会议
合肥
英文
1-12
2017-06-15（万方平台首次上网日期，不代表论文的发表时间）