Pulmonary pharmacokinetic in rat plasma after intratracheal aerosolization of Tanreqing solution
Tanreqing solution(TRQ)based on the traditional Chinese medicine,is used to cure upper respiratory tract infections.In present studies,a rapid ultra high performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS)method was developed for the simultaneous analysis of baicalin,oroxylin A-7-O-β-D-glucoronide and chlorogenic acid in rat plasma,a comparative pharmacokinetic study was conducted in rats after intratracheal aerosolization and intravenous injection of TRQ.The results of analytical method validation test showed high sensitivity,accuracy and satisfying recovery.The results of pulmonary pharmacokinetic showed intratracheal aerosolization had similar rapid absorption and clearance to intravenous injection.The plasma concentrations of intratracheal aerosolization group declined much more slowly than intravenous administration group.The t1/2(h)values were 0.90 and 1.22 for baicalin,0.47 and 0.17 for oroxylin A-7-O-β-D-glucoronide,0.22 and 0.13 for chlorogenic acid,respectively.
Tanreqing solution Pulmonary pharmacokinetic Baicalin Oroxylin A-7-O-β-D-glucoronide Chlorogenic acid UPLC-MS/MS Intratracheal aerosolization Miniature liquid aerosolizer
Cui Li Siyu Liu Gan Luo Guohua Wang Longfei Lin BaoxianZhang Qixia Nie
China academy of Chinese medical sciences,Beijing,100102,China;Institute of Chinese material medica, The Institutes of Biomedical Sciences of Shanghai Medical School,Fudan University,Shanghai,200032,Ch Institute of Chinese material medica,China academy of Chinese medical sciences,Beijing,100102,China
国内会议
合肥
英文
1-15
2017-06-10（万方平台首次上网日期，不代表论文的发表时间）