CLINICOPATHOLOGICAL SIGNIFICANCE OF C-MYC IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA
Aim Esophageal squamous cell carcinoma(ESCC)is one of the most common malignant tumors.The oncogene c-MYC is thought to be important in the initiation,promotion,and therapy resistance of cancer.In the present study,we aim to investigate the clinicopathologic roles of c-MYC in ESCC tissue.Methods: The present study is aimed at discovering and analyzing c-MYC expression in a series of human esophageal tissues.95 ESCC samples were analyzed by the WB and IHC techniques.Then,correlation of c-MYC expression with clinicopathological features of ESCC patients was statistically analyzed.Results In most ESCC cases,the c-MYC expression was positive in tumor tissues,The PR(positive rate)of c-MYC expression in tumor tissues was 61.05%(58/95),obviously higher than the adjacent normal tissues(ANT)(8.42%,8/92)and AHT(19.75%,16/95).Over-expression of the c-MYC was detected in 61.05%(58 of 95)ESCCs,which was significantly correlated with the degree of differentiation(P=0.004).The PR of c-MYC was 41.5%(17/41)in T1+T2 esophageal tissues,and 74.1%(40/54)in T3+T4 esophageal tissues,with a significantly statistical difference(P=0.001).The PR of c-MYC was 45.0%(18/40)in Ⅰ+Ⅱ esophageal tissues,and 72.2%(39/55)in Ⅲ+Ⅳ esophageal tissues,with a significantly statistical difference(P=0.011).The c-MYC expression strongly correlated with clinical staging(P=0.011),differentiation degree(P=0.004),lymph node metastasis(P=0.003)and invasion depth(P=0.001)of patients with ESCC.Conclusion: The c-MYC was differentially expressed in a series of human esophageal tissues,and the aberrant c-MYC expression could be a potential factor in carcinogenesis and progression of ESCC.There was a statistical signification for c-MYC in ESCC patients to analyze clinicopathological features.It possibly becomes a new diagnostic indicator of ESCC.
Esophageal squamous cell carcinoma c-MYC Western blot clinicopathology immunohistochemistry
Xiangdong Niu Hui Cai Xiaojun Yang Haizhong Ma Shixun Ma Yupeng Zhang Yifeng Chen
Gansu University of Traditional Chinese Medicine,Lanzhou,730000,China Gansu Provincial Hospital,Lanzhou,730000,China Ningxia Medical University,Yinchuan,750000,China
国内会议
北京
英文
1-13
2017-05-19（万方平台首次上网日期，不代表论文的发表时间）