Plasma and tumor levels of Linc-pint are diagnostic and prognostic biomarkers for pancreatic cancer
Long intergenic non-protein coding RNA,p53 induced transcript(Linc-pint)is a long noncoding RNA(lncRNA)that regulates tumor cell viability and proliferation.We used qRT-PCR and RNA FISH analysis to evaluate Linc-pint levels in the plasma and tumor tissues of pancreatic cancer(PCa)patients.Our data demonstrate that Linc-pint expression is lower in plasma samples from PCa patients than from healthy individuals,and indicate that plasma Linc-pint levels are more sensitive than CA19-9 for detecting PCa.Our data also show that Linc-pint levels are lower in PCa tumors than in adjacent tissues,carcinoma of the ampulla of Vater(CAV)and cholangiocarcinoma(CCA),and suggest that Linc-pint could be used for distinguishing the cause of malignant obstructive jaundice.Low plasma Linc-pint levels correlate with tumor recurrence,while low tumor Linc-pint levels correlate with poor prognosis for PCa patients after pancreatectomy.These results thus indicate that low plasma Linc-pint expression could serve as a minimally invasive biomarker for early PCa detection,and that low Linc-pint levels in PCa tumors could be used for predicting patient prognosis.
pancreatic cancer prognosis biomarker Linc-pint CA19-9
李乐 张广权 陈华 赵忠杰 陈宏泽 刘欢 王刚 贾月辉 孔瑞 王拥卫 孙备
哈尔滨医科大学附属第一医院 哈尔滨市南岗区邮政街23号
国内会议
北京
英文
1-19
2017-05-19（万方平台首次上网日期，不代表论文的发表时间）