Radical antegrade modular pancreatosplenectomy versus standard procedure in treatment of left-sided pancreatic cancer:a systemic review and meta-analysis
Radical antegrade modular pancreatosplenectomy(RAMPS)first reported by Strasberg in 2003,attracts more and more attention in treatment of left-sided pancreatic cancer.Limited cases requiring RAMPS make it difficult to perform any prospective randomized trial of RAMPS versus standard procedure.Therefore,systemic review and meta-analysis of the current retrospective data is necessary and useful to clarify the role the RAMPS.We performed this systemic review and meta-analysis comparing RAMPS verse standard procedure.Six retrospective cohort studies were included in our analysis with a total number of 378 patients.Meta-analysis showed RAMPS was in favor of higher R0 resection”OR 95%CI,2.19(1.16~4.13); P=0.02” and more lymph node harvested”WMD 95%CI,7.06(4.52~9.60); P<0.01” when comparing with standard procedure.However,no statistically significant difference was found when concerning recurrence rate”OR 95%CI,0.66(0.40~1.09); P=0.10”,overall survival(OS)”OR 95%CI,0.65(0.42~1.00); P=0.05” and disease-free survival(DFS)”OR 95%CI,1.02(0.62~1.68); P=0.93”.From current data,RAMPS should not be performed routinely in clinical practice in terms of recurrence,OS and DFS.
Feng Cao Jia Li Ang Li Yu Fang Fei Li
Department of General Surgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,PR China
国内会议
北京
英文
1-16
2017-05-19（万方平台首次上网日期，不代表论文的发表时间）