HIF3A DNA methylation is associated with childhood obesity and ALT
Gene polymorphisms associated so far with BMI can explain only 1.18-1.45% of observed variation in BMI.Recent studies suggest that epigenetic modifications (DNA methylation) could contribute to explain part of the missing heritability, and two epigenetic genome-wide analysis studies (EWAS) have reported that HIF3A methylation was associated with BMI or BMI change.We therefore assessed whether the HIF3A methylation is associated with obesity and other obesity-related phenotypes in Chinese children.The subjects included 110 severe obese cases aged 7-17y and 110 normal-weight controls matched by age and gender for measurement of blood DNA methylation levels at the HIF3A gene locus using the Sequenom”s MassARRAY system.We observed significantly higher methylation levels in obese children than in controls at positions 46801642 and 46801699 in HIF3A gene (P<0.05), and found positive associations between methylation and ALT levels adjusted by gender, age and BMI at the position 46801699 (r=0.200, P =0.016).These results suggest that HIF3A DNA methylation is associated with childhood obesity,and has a BMI-independent association with ALT.The results provide evidence for identifying epigenetic factors of elivated ALT and may be useful for risk assessment and personalized medicine of liver diseases such as NAFLD.
HIF3A DNA methylation plasma ALT level childhood obesity NAFLD BMI
Shuo Wang Jieyun Song Yide Yang Yining Zhang Haijun Wang Jun Ma
All authors are from the Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China
国内会议
中华预防医学会儿少卫生分会换届及第十届全国学术交流会、中国健康促进与教育协会学校分会换届及第五届全国学术交流会
北京
英文
339-348
2016-11-01（万方平台首次上网日期，不代表论文的发表时间）