Investigation of genetic susceptibility to nonspecific digestive disorder between TYK2, JAK1, and STAT3 genes in rabbits
Tyrosine kinase 2 (TYK2), Janus kinase 1 (JAK1), and signal transducer and activator of transcription 3 (STAT3) all play critical roles in innate and acquired immunity.In this study, we investigated the association between the TYK2, JAK1, and STAT3 genes and genetic susceptibility to nonspecific digestive disorder (NSDD) in rabbits.Five coding single-nucleotide polymorphisms (cSNPs) in TYK2 were detected in New Zealand White (NZW) rabbits with direct sequencing, and two of them, c.1477 (C > T) and c.2013 (C > T), from two different linkage disequilibrium blocks, were further genotyped.A case control association analysis revealed that allele C (c.1477) in TYK2 increases the risk of NSDD (odds ratio ”OR”: 1.21;95% confidence interval ”CI” 1.036 2.145;P =0.021), whereas allele C (c.2013) plays a potentially protective role against NSDD (OR: 0.41;95% CI 0.2996 0.5705;P < 0.001).A gene gene interaction analysis with a multifactor dimensionality reduction (MDR) method indicated that the combination of c.1477 from TYK2 and c.831 from STAT3 is associated with the susceptibility to NSDD (OR: 7.2567;95% CI: 4.7306 11.1317;P < 0.0001).Together, our data demonstrate that the TYK2 gene is associated with NSDD in rabbits.The TYK2, JAK1, and STAT3 combination model may be used to assist breeders in selecting rabbits.
TYK2 JAK1 STAT3 genetic susceptibility MDR rabbit
Fu lu Zhao Ming-de Chen Shi-yi Jia Xian-bo Lai Song-jia
Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China;De Department of SPF Experimental Animal, Sichuan Medical University, Luzhou 646000, China Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, China
国内会议
银川
英文
1-11
2016-06-01（万方平台首次上网日期，不代表论文的发表时间）