Developing a rat model of dilated cardiomyopathy with improved survival
To compare the standard administration protocol to a new administration (1 mg/kg twice a week) to see if dilated cardiomyopathy would still occur but with reduced mortality.Thirty SD rats were divided into three groups: normal control saline group (control), low dose group (1 mg/kg twice a week;Dox 1), and high dose group (2 mg/kg once a week;Dox 2).Results The mortality rate for Dox 2 group was 50% compared to 0% for control and 20% for Dox 1 (both p<0.05).As shown by echocardiography, both Dox groups exhibited significant chamber dilatation, with increased end-diastolic and end-systolic dimensions of left ventricle (LV) as well as reduced fractional shortening and ejection fraction (all p<0.05 vs.control).Plasma brain natriuretic peptide (BNP) concentrations were significantly increased in both Dox regimens.Histology revealed vacuolization, intracytoplasmic granulation, necrosis and interstitial fibrosis in LVs ofboth Dox groups.By 18F-fluoro-deoxyglucose-positron emission tomography (18FDG-PET) myocardial metabolism imaging revealed significant decreasedstandarduptakevalueof 2-deoxy-2-(18F) fluoro-D-glucoseuptake,demonstrating that myocardial viability was decreased to the same extent in Dox 1 and Dox 2 groups.Conclusions Doxorubicin given at both regimens induced dilated cardiomyopathy, while administration at the lower dose reduced mortality rate.
doxorubicin dilated cardiomyopathy animal models 18FDG-PET
Lijuan Shen Yonghua Zhou Lan Li Qingmin Xing Yongliang Xu Shu Lu
Wuxi Hospital of traditional Chinese Medicine, Nanjing University of Chinese Medicine Affiliated Wux Key Laboratory of National Health and Family Planning Commission on Parasitic Disease Control and Pr
国内会议
银川
英文
22-28
2016-06-01（万方平台首次上网日期，不代表论文的发表时间）