High-frequency repetitive transcranial magnetic stimulation promotes neurogenesis, and reduces subacute ischemic brain damage possibly through BDNF signaling pathways in a rat model of ischemic stroke
Repetitive transcranial magnetic stimulation(rTMS)has rapidly become an attractive therapeutic approach for stroke.However, its underlying mechanism remains elusive.This study is aimed to investigate whether high-frequency rTMS can promote neurogenesis and to examine the role of BDNF-TrkB pathways in rTMS-induced functional recovery in a rat model of middle cerebral artery occlusion (MCAO).Ischemic rats received either high-frequency rTMS at 20Hz or intermittent theta burst stimulation (iTBS) daily for 2 weeks.The results showed that both of them significantly improved neurological function and reduced infarct volume.Moreover, 20Hz rTMS and iTBS significantly promoted neurogenesis as evidenced by the increased Ki67/DCX-positive and Ki67/Nestin-positive cells in ischemic hemisphere.These beneficial effects were in conjunction with the elevated BDNF and TrkB proteins, indicating that high-frequency rTMS promotes neurogenesis and reduces subacute ischemic brain damage possibly through BDNF signaling pathways.
rTMS neural progenitor cell BDNF MCAO
Jing Luo Liying Zhang Qingjie Zhang Haiqing Zheng Lili Li Zhong Pei Xiquan Hu
Department of Rehabilitation Medicine, the Third Affiliated Hospital, Sun Yat-sen University, Guangz Department of Neurology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, Ch
国内会议
广东韶关
英文
68-87
2016-04-21（万方平台首次上网日期，不代表论文的发表时间）