Quercetin Mediates 3-Catenin in Pancreatic Cancer Stem-Like Cells
Objective: The aim of this study is to explore how quercetin interacts with pancreatic cancer stem-like cells and the mechanism underlying the effective quercetin-mediated suppression.Methods: A model of pancreatic cancer stem-like cells was generated by using a sphere formation culture system.A comparative analysis was performed between the parent cells and pancreatic cancer stem-like cells with a related treatment strategy focusing on cancer stem cell (CSC) properties and drug-resistance-related mechanisms in vitro.Results: Our data show that pancreatic cancer stem-like cells have greater resistance to gemcitabine and stronger CSC properties compared with the paint cells.In contrast to the pancreatic cancer stem-like cells, overexpression of β-catenin was observed in the parent cells.Quercetin suppressed proliferation, invasion and self-renewal capacity, and CSC surface markers expression, with alterations of β-catenin in pancreatic cancer stemlike cells.The combination of quercetin and gemcitabine can reduce tumor growth and decrease drug resistance in pancreatic cancer.Conclusions: β-Catenin plays an important role in maintenance and progression of pancreatic cancer.Targeting β-catenin using quercetin combined with gemcitabine may be a treatment strategy to improve prognosis in patients with pancreatic cancer.
quercetin pancreatic cancer cancer stem cell β-catenin
Caineng Cao Lixin Sun Wenxiu Mo Lichao Sun Jingwei Luo Zhihua Yang Yuliang Ran
Department of Radiation Oncology,Cancer Institute (Hospital),Chinese Academy of Medical Sciences,Pek State Key Laboratory of Molecular Oncology Cancer Institute (Hospital),Chinese Academy of Medical Sc Department of Radiation Oncology,Cancer Institute (Hospital),Chinese Academy of Medical Sciences,Pek
国内会议
北京
英文
455-460
2016-01-09（万方平台首次上网日期，不代表论文的发表时间）