Results and prognostic factors of 3-dimensional conformal radiotherapy and intensity-modulated radiotherapy for esophageal carcinoma
The aim of this study was to summarize the outcomes and prognostic factors of 3-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for esophageal carcinoma in our institute.Five hundred ninety-two patients received radiotherapy for esophageal carcinoma (123 with 3D-CRT, 469 with IMRT) from January 2002 to March 2012.Three hundred sixty patients received radiotherapy alone and 232 patients received radiotherapy and chemotherapy.The endpoints were overall survival (OS), progression-free survival (PFS).Kaplan-Meier analysis was used to calculate endpoints, the log-rank test for univariate analysis, and multivariate analysis to identify independent prognostic factors.The median follow-up time was 22.6 months and the median dose was 60 Gy.The 1-year OS, PFS were 65.3%, 52.1%;the 3-year OS, PFS were 34.0%, 28.0%;and the 5-year OS, PFS were 23.5%, 19.6%.The median OS was 20 months (95% CI: 17.9-22.1 months) and the median PFS was 14 months (95% CI: 11.8-16.2 months).Univariate analysis indicated that sex, N-stage,M-stage, TNM stage, radiotherapy dose, weight loss before treatment, smoking, and drinking affected OS and PFS (p < 0.05 for all).T-stage affected OS (p =0.042), but no significant influence on PFS (p =0.101).The independent prognostic factors for better OS and PFS were early clinical TNM stage, high radiotherapy dose, and female sex (p < 0.05 for all).The results of esophageal carcinoma patients treated with 3D-CRT and IMRT with or without chemotherapy were promising.Clinical TNM stage, radiotherapy dose and sex were the independent prognostic factors for OS and PFS.
esophageal carcinoma 3-dimensional conformal radiotherapy intensity-modulated radiotherapy prognostic factor
L.TAN Z.XIAO H.ZHANG D.CHEN Q.FENG Z.ZHOU J.LV J.LIANG Z.HUI L.WANG W.YIN
Department of Oncology,the First Affiliated Hospital of Harbin Medical University,Harbin,China Department of Radiation Oncology,Cancer Hospital,Chinese Academy of Medical Sciences(CAMS) and Pekin
国内会议
北京
英文
471-480
2016-01-09（万方平台首次上网日期，不代表论文的发表时间）