Salvage radiotherapy in patients with local recurrent esophageal cancer after radical radiochemotherapy
Purpose: The aim of this study was to evaluate the salvage radiotherapy outcome in patients with local recurrent esophageal cancer after radical radiochemotherapy (RCT).Methods: A total of 114 patients with local recurrent esophageal squamous cell carcinoma after initial radical RCT were retrospectively analyzed.Fifty-five (55) patients belonged to the salvage radiotherapy group (SR group) and 59patients to the non-salvage radiotherapy group (NSR group).Results: The median survival time after-recurrence was 4 months in all patients.The 1, 2, 3 year overall survival (OS)rates were 83.6%, 41.8% and 21.8% respectively in the SR group, and 57.6%, 16.9%, and 8.5% in the NSR group.The6-month and 1-year survival rates after-recurrence were 41.8% and 16.4% respectively in the SR group, and 11.9%and 3.4% respectively in the NSR group.A salvage radiation dose > 50 Gy after initial radical RCT, improved the survival of patients with local recurrent esophageal cancer.Three patients (5.45%) from the SR group showed more than 3-grade radiation pneumonitis.In addition, esophageal fistula/perforation was observed in 11 cases (20.0%) in the SR group and in 8 cases (13.6%) in the NSR group.Conclusions: Salvage treatment after definitive RCT may improve the overall survival and survival after-recurrence of patients with local recurrent esophageal cancer.
Salvage radiotherapy Esophagus Squamous cell carcinoma Local recurrence
Zhi-guo Zhou Chan-jun Zhen Wen-wen Bai Ping Zhang Xue-ying Qiao Jun-li Liang Xian-shu Gao Shuo-shuo Wang
Department of Radiation Oncology,Peking University First Hospital,Beijing 100034,China;Department of Department of Radiation Oncology,Fourth Hospital of Hebei Medical University,Shijiazhuang,Hebei 0500 Department of Radiation Oncology,Peking University First Hospital,Beijing 100034,China
国内会议
北京
英文
654-660
2016-01-09（万方平台首次上网日期，不代表论文的发表时间）