Genetic Association between the XPG Asp1104His Polymorphism and Head and Neck Cancer Susceptibility: Evidence Based on a Meta-Analysis

摘要：

　　Background: Previous studies evaluating the association between the xeroderma pigmentosum group G (XPG) Asp1104His polymorphism and head and neck cancer susceptibility have proven controversial.This meta-analysis of the literature was performed to obtain a more precise estimation of the relationship.Materials and Methods: We systematically searched PubMed, Embase and Web of Science with a time limit of Dec 18,2014.Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association.Results: We performed a meta-analysis of eight published case-control studies, including 3,621 cases and 5,475 controls.Overall, no significant association was found between the XPG Asp1104His polymorphism and head and neck cancer susceptibility under all genetic models.In the subgroup analysis by ethnicity, the XPG Asp1104His polymorphism had statistically significant association with elevated head and neck cancer risk under CC vs GG (OR=1.24, 95% CI=1.00~1.54) and the recessive model (OR=1.22, 95%CI=1.01~1.46) in Asian populations.A similar result was found under CC vs GG (OR =1.22, 95%CI =1.01~1.47) in the population based subgroup by source of control.When performed by tumor site, the XPG Asp1104His polymorphism had statistically significant association with elevated laryngeal cancer under all genetic models (CC vs GG: OR=1.59, 95% CI=1.16~2.19;GC vs GG: OR=1.38, 95%CI=1.10~1.72;dominant model: OR=1.42, 95% CI=1.15~1.74;recessive model: OR=1.36,95% CI=1.02~1.81).Conclusions: This meta-analysis suggested that the XPG Asp1104His polymorphism is a risk factor for head and neck cancer susceptibility, especially for laryngeal cancer and in Asian populations.

关键词： XPG Asp1104His polymorphism head and neck cancer meta-analysis

作者: Hua-Yong Jiang Yong Zeng Wei-Dong Xu Chuan Liu Ya-Jie Wang Ya-Di Wang

作者单位: Department of Radiation Oncology,General Hospital of Beijing Military Command,Beijing Department of Cardiothoracic Surgery,Shaoxing People”s Hospital,Shaoxing Hospital of Zhejiang Univer Cancer Center,Shanghai East Hospital,Tongji University School of Medicine,Shanghai,China

会议类型: 国内会议

会议名称: 2015年北京放射肿瘤年会

会议地点: 北京

会议语种:英文

页码: 690-696

在线出版日期: 2016-01-09（万方平台首次上网日期，不代表论文的发表时间）