The Efficacy and Safety of Wenxin Granule and Amiodarone for Rhythm Control in the Patient with Atrial Fibrillation:A Systematic Review and Meta-Analysis
OBJECTIVE To systematically evaluate the efficacy and adverse reaction of Wenxin Granule on rhythm control in the patient with atrial fibrillation either as a sole or in combination with amiodarone.METHODS Search strategy-Databases retrieved were the Cochrane Central Register of Controlled Trials, PubMed, Embase, the Chinese Biomedicine Database, CNKI,Wanfang system database and CQVIP-database for all relevant studies.The cut-off date for the search was January 2014.Selection criteria-All randomized controlled trials (RCTs) with enrolled patients of all ages with AF were included.The primary outcome were the incidence of adverse events and the rate of rhythm control which was defined as the cardioversion and sinus rhythm maintenance in AF patients.Data collection and analysis--For dichotomous outcomes, the rate of rhythm control and the incidence of adverse drug reaction were calculated as a relative risk with 95% confidence intervals in a fixed effects model.RESULTS A total of 15 trails(1,539 participants)were included in the meta-analyses.Compared with amiodarone, the group of Wenxin granule did not show statistical significance in rhythm control (RR:0.91;95%CI:”0.75,1.09”, P=0.30)but lower adverse events (RR0.54, 95%C1:”0.32,0.90”,P=0.02)while the group of Wenxin granule combined with amiodarone increased rate of sinus rhythm maintenance (RR: 1.34;95%CI :”1.22,1.47”;P<0.01)and did not increase the incidence of adverse events (RR 0.51, 95%CI: ”0.32,0.80”,P<0.01).Trim and fill method was performed to correct the pooled effect for the funnel pot asymmetry (adjusted value of RR=1.172,95%CI:”1.088,1.264”).CONCLUSION The benefit of Wenxin granule as a sole or adjuvant agent on maintaining sinus rhythm in AF patients are promising.However there were some methodological defects in the included studies.Further rigorously designed trials are needed to substantiate its use.
王创畅 吴伟 李荣 吴辉 彭锐 江楠 卿立金 罗川晋
国内会议
广州
英文
213-224
2016-11-01（万方平台首次上网日期，不代表论文的发表时间）