Treatment of nasopharyngeal carcinoma using simultaneous modulated accelerated radiation therapy via helical tomotherapy:a phase Ⅱ study

摘要：

　　Background.The aim of the study was to evaluate short-term safety and efficacy of simultaneous modulated accelerated radiation therapy (SMART) delivered via helical tomotherapy in patients with nasopharyngeal carcinoma (NPC).Methods.Between August 2011 and September 2013, 132 newly diagnosed NPC patients were enrolled for a prospective phase Ⅱ study.The prescription doses delivered to the gross tumor volume (pGTVnx) and positive lymph nodes (pGTVnd), the high risk planning target volume (PTV1), and the low risk planning target volume (PTV2), were 67.5 Gy (2.25 Gy/F), 60 Gy (2.0 Gy/F), and 54 Gy (1.8 Gy/F), in 30 fractions, respectively.Acute toxicities were evaluated ac cording to the established RTOG/EORTC criteria.This group of patients was compared with the 190 patients in the retrospective P70 study, who were treated between September 2004 and August 2009 with helical tomotherapy, with a dose of 70-74 Gy/33F/6.5W delivered to pGTVnx and pGTVnd.Results.The median follow-up was 23.7 (12-38) months.Acute radiation related side-effects were mainly problems graded as 1 or 2.Only a small number of patients suffered from grade 4 leucopenia (4.5%) or thrombocytopenia (2.3%).The local relapse-free survival (LRFS), nodal relapse-free survival (NRFS), local-nodal relapse-free survival (LNRFS), distant metastasis-free survival (DMFS) and overall survival (Os) were 96.7%, 95.5%, 92.2%, 92.7% and 93.2%, at 2 years, respectively, with no significant difference compared with the P70 study.Condusions.SMART delivered via the helical tomotherapy technique appears to be associated with an acceptable acute toxicity profile and favorable shorf-term outcomes for patients with NPC.Long-term toxicities and patient outcomes are under investigation.

关键词： nasopharyngeal carcinoma simultaneous modulated accelerated radiation therapy helical tomotherapy acute toxicities,clinical outcome

作者: Lei Du Xin Xin Zhang Lin Chun Feng Jing Chen Jun Yang Hai Xia Liu Shou Ping Xu Chuan Bin Xie Lin Ma

作者单位: Department of Radiation Oncology, Chinese PLA General Hospital Beijing, China;Department of Radiatio Department of Otorhinolayngology, Chinese PLA General Hospital, Beijing, China Department of Radiation Oncology, Chinese PLA General Hospital Beijing, China Department of Oncology, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Hena

会议类型: 国内会议

会议名称: 2016年北京市肿瘤放疗年会

会议地点: 北京

会议语种:英文

页码: 61-68

在线出版日期: 2016-10-01（万方平台首次上网日期，不代表论文的发表时间）