Overexpression of B7-H3 correlates with aggressive clinicopathological characteristics in non-small cell lung cancer
Previous studies have investigated the prognostic significance of B7 homolog 3 (B7-H3) in non-small cell lung cancer (NSCLC), however, the results remain controversial.This study was aimed to determine the correlation between B7-H3 and survival as well as clnicalpathological characteristics in NSCLC using meta-analysis, We searched the electronic databases of PubMed, Embase, Web of Science,and China National Knowledge Infrastructure (CNKI) for relevant studies up to October 9, 2016.Pooled hazard ratios (HRs) and 95% confidence intervals (Cis) were used to estimate the impact of B7-H3 on overall survival (OS).Combined odds ratios (Ors) and 95%Cis were utilized to evaluate the correlations between B7-H3 and clinicalpathological features.This meta-analysis finally included 7 studies with 864 patients.The results showed that B7-H3 had no significant association with OS (HR=0.88, 95%CI: 0.36-2.13, p=0.776).High B7-H3 expression was a significant indicator of lymph node metastasis (OR=3.92, 95% CI: 2.65-5.81, p<0.001), and advanced TNM stage (OR=3.53, 95%CI: 2.45-5.09, p<0.001).B7-H3 has the potential to serve as a marker of tumor aggressiveness and lymph node metastasis in NSCLC.However, due to several limitations, further large-scale studies are needed to validate our results.
meta-analysis B7-H3 prognosis lung cancer clinical
Shanshan Wu Xiangfei Zhao Sudong Wu Rui Du Qi Zhu Henghu Fang Xinhong Zhang Chunyang Zhang Wei Zheng Jihua Yang Huasong Feng
Postgraduate Team, Chinese PLA General Hospital, Beijing 100853, China;Department of Radiation Oncol Department of Radiation Oncology, Navy General Hospital, Beijing 100048, China
国内会议
北京
英文
135-141
2016-10-01（万方平台首次上网日期，不代表论文的发表时间）