Crosstalk between autophagy and intracellular radiation response (Review)

摘要：

　　Autophagy induced by radiation is critical to cell fate decision.Evidence now sheds light on the importance of autophagy induced by cancer radiotherapy.Traditional view considers radiation can directly or indirectly damage DNA which can activate DNA damage the repair signaling pathway,a large number of proteins participating in DNA damage repair signaling pathway such as p53, ATM, PARP1, FOXO3a,mTOR and SIRTI involved in autophagy regulation.However,emerging recent evidence suggests radiation can also cause injury to extranuclear targets such as plasma membrane,mitochondria and endoplasmic reticulum (ER) and induce accumulation of ceramide, ROS, and Ca2+ concentration which activate many signaling pathways to modulate autophagy.Herein we review the role of autophagy in radiation therapy and the potent intracellular autophagic triggers induced by radiation.We aim to provide a more theoretical basis of radiation-induced autophagy, and provide novel targets for developing cytotoxic drugs to increase radiosensitivity.

关键词： radiation autophagy DNA damage mitochondrial damage ER stress

作者: LELIN HU HAO WANG LI HUANG YONG ZHAO JUNJIE WANG

作者单位: Department of Radiation Oncology, Peking University Third Hospital, Haidian, Beijing 100191;Departme Department of Radiation Oncology, Peking University Third Hospital, Haidian, Beijing 100191 State Key Laboratory of Membrane Biology, Institute of Zoology,Chinese Academy of Sciences, Beijing

会议类型: 国内会议

会议名称: 2016年北京市肿瘤放疗年会

会议地点: 北京

会议语种:英文

页码: 354-363

在线出版日期: 2016-10-01（万方平台首次上网日期，不代表论文的发表时间）