SS31 peptide improved age-related apoptotic status in SAMP8 mice
Alzheimer”s disease (AD) is a common neurodegenerative disease associated with aging and widespread neuronal death ,which via an apoptotic mechanism probably.Apoptosis research is a rapidly developing area, but the role of apoptosis in AD is still controversial.In this study, we aimed to investigate the effects of aging and SS31 on the mitochondria-related apoptotic status in SAMP8 mice.Western blot and real-time reverse transcription-quantitative PCR analysis revealed that aging increased the expression of BCL-2 associated X protein (BAX) , and Dynamin related protein 1 (DRP 1), as an apoptotic fission protein, and decreased the expression of B-cell lymphoma-2 (BCL-2) in the hippocampus of SAMP8 mice.Moreover, our results indicated that SS31 down-regulated the expression of BAX and DRP 1, and up-regulated the expression of BCL-2 in the hippocampus of SAMP8 mice.In conclusion, our findings demonstrate that SAMP8 mice show an age-related enhanced apoptotic status,while SS31 can play a potentially protective role in AD and age-related disorders by anti-apoptotic mechanism.
Alzheimer”s disease SAMP8 mice SS31 BAX BCL-2 DRP1
Xu XiaoJing Jia YanLi Huo TianTian Jia Qian Zhao JingRu Dong XiaoLi Wang JianHua
Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei 050051, China;Graduate School, Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei 050051, China Department of Neurology, Third Hospital of Xingtai, Xingtai, Hebei 054000, China
国内会议
贵阳
英文
43-45
2016-08-01（万方平台首次上网日期，不代表论文的发表时间）