Role of dynamin-related protein 1 in sepsis-induced myocardial inflammation: conversion of cardiomyocytes into a proinflammatory phenotype

摘要：

　　Dynamin-related protein 1 (Drp1) is a regulator of mitochondrial fission and cell death pathways.We assessed the role of Drp1 in sepsis-induced myocardial inflammation.Six hours after induction of sepsis (i.p.injection of fecal material), PMN infiltration of the myocardial interstitium was evident.This inflammatory response was ameliorated by a Drp1 inhibitor, Mdivi-1.Challenge of cardiomyocytes with septic plasma resulted in Drp1 activation and converted the cardiomyocytes to a proinflammatory phenotype (they produced and secreted the chemokines, LIX and KC);effects blunted by Mdivi-1.Collectively, these findings indicate that Drp 1 could be an effective target for treatment of sepsis.

作者: Qian Liu Hao Wang Aibin Tao Raymond Kao Claudio Martin Tao Rui

作者单位: Division of Cardiology, Department of Medicine, the Affiliated People”s Hospital of Jiangsu Universi Division of Cardiology, Department of Medicine, the Affiliated People”s Hospital of Jiangsu Universi Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada;Critical Care W Division of Cardiology, Department of Medicine, the Affiliated People”s Hospital of Jiangsu Universi

会议类型: 国内会议

会议名称: 第五届中国心脏重症大会(第二届中国·国际重症医学大会、第一届中国心脏康复大会、第一届心脏人工智能医疗大会、第一届重症心脏疾病的精准医疗大会、2016华夏医学科技论坛-心脏重症论坛)

会议地点: 北京

会议语种:英文

页码: 13-25

在线出版日期: 2016-06-17（万方平台首次上网日期，不代表论文的发表时间）