Bevacizumab plus cisplatin and helical tomotherapy in treatment of locally advanced nasopharyngeal carcinoma

摘要：

　　Background: In recent years, chemotherapy, radiotherapy, and targeted drugs have been respectively used in nasopharyngeal carcinoma.In our research, we combined all of them for better curative effects,Materials and methods: Thirty patients with histologically confirmed stage Ⅲ~Ⅳ (without distant metastasis) nasopharyngeal carcinoma were recruited between December 2013 and October 2014 with strict eligibility requirements and exclusion criteria.Bevacizumab 5 mg/kg,80 mg/m2 cisplatin and 67.5 Gy radiotherapy (helical tomotherapy ”TOMO”) was given according to standard treatment protocols.Results: After 3 months, 24 complete responses (80%) and six partial responses (40%) were observed in our research.Twenty-four patients (80%) experienced oropharyngeal mucositis,26% patients experienced weight loss caused by pharyngeal pain and dysphagia caused by oropharyngeal mucositis.Conclusion: Bevacizumab plus cisplatin and TOMO in treatment of locally advanced nasopharyngeal carcinoma can increase curative effects with low side effects and toxicities.

关键词： bevacizumab cisplatin helical tomotherapy (TOMO) nasopharyngeal carcinoma

作者: Jianxiong Li Zhifei Zhao Xuan Wu Jie Yao Lin Ma Rui Ye Baolong Niu Lanqing Liang Xiao Zhao Qianqian Wang

作者单位: Radiology Department, Cancer Center, The General Hospital of the People”s Liberation Army,Beijing, P Department of Oncology,The People”s Liberation Army 161 Hospital,Wuhan, People”s Republic of China

会议类型: 国内会议

会议名称: 2015年北京放射肿瘤年会

会议地点: 北京

会议语种:英文

页码: 282-286

在线出版日期: 2016-01-09（万方平台首次上网日期，不代表论文的发表时间）