Update report of T4 classification nasopharyngeal carcinoma after intensity-modulated radiotherapy: An analysis of survival and treatment toxicities
Objective: To evaluate the long-term survival outcomes and toxicity of a larger series of patients with non-metastatic T4 classification nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT).Materials and methods: From March 2004 to June 2011,335 non-metastatic T4 classification NPC patients treated by IMRT were analyzed retrospectively.Treatment induced toxicities were scored according to the Common Terminology Criteria for Adverse Events version 3.0.Results: With a median follow-up time of 53.6 months (range, 2.8-114.9 months), the 5-year local failure-free survival (LFFS), regional failure free survival (RFFS), distant failure-free survival (DFFS), and overall survival (OS) were 84.1%, 92.2%, 74.1%, and 63.0%, respectively.At their last follow-up visit, 118 patients (35.2%) had developed treatment failure.Distant metastasis was the major failure pattern after treatment.The most common toxicities were mainly in grade 1 or 2.Concurrent chemotherapy failed to improve survival rates for patients with T4 classification NPC.Conclusion: The results of T4 classification NPC treated by IMRT were excellent, and distant metastasis was the most commonly failure pattern.Treatment-related toxicities were well tolerable.The role of concurrent chemotherapy for T4 classification NPC needs to be further investigated in the era of IMRT.
Intensity-modulated radiotherapy IMRT Prognosis T4 classification Nasopharyngeal carcinoma
Cai-neng Cao Jin-wei Luo Li Gao Jun-lin Yi Xiao-dong Huang Kai Wang Shi-ping Zhang Yuan Qu Su-yan Li Jian-ping Xiao Zhong Zhang Guo-zhen Xu
Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union
国内会议
北京
英文
305-309
2016-01-09（万方平台首次上网日期，不代表论文的发表时间）