Inherently poor survival of elderly patients with nasopharyngeal carcinoma
Background.The purpose of this study was to determine the features of the eldedy patient with nasopharyngeal carcinoma (NPC).Methods.The medical records of 212 patients with NPC, aged >65 years, and receiving radiotherapy were retrospectively reviewed.Comorbidity was rated using the Charlson Comorbidity Index (CCI).Results.Twenty-four patients (11.3%) scored >3 and 188 patients (88.7%) scored <3 rated by CCI.The median actuarial irradiated dose of the nasopharynx was 72 Gy (range, 20-94 Gy) with 87.3% patients receiving >70 Gy.0ne hundred fifty-four patients had stage Ⅲ/Ⅳ disease.The actuarial local control, cancer-specific survival (CSS), and overall survival (0S) rates at 5 years were 68.8%, 63.5%, and 47.0%, respectively.0n multivariate analysis, stage (hazard ratio ”HR”, 1.489;95% confidence interval ”CI”, 1.168-1.897;p =.001), the technique of radiotherapy (HR,0.674;95% CI, 0.476-0.953;p =.025), and anemia (HR, 3.081;95% CI,1.624-5.845;p =.001) were independent prognostic factors.Conclusion.The elderly patients with NPC may inherently predict poor outcomes.
nasopharyngeal carcinoma elderly radiotherapy comorbidity prognosis
Ye Zhang Jun-Lin Yi Xiao-Dong Huang Guo-Zhen Xu Jian-Ping Xiao Su-Yan Li Jing-Wei Luo Shi-Ping Zhang Kai Wang Yuan Qu Li Gao
Department of Radiation 0ncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People”s Republic of China
国内会议
北京
英文
313-318
2016-01-09（万方平台首次上网日期，不代表论文的发表时间）