UHPLC-Q-TOF-MS和UPLC-MS/MS技术快速分析何首乌提取物入血成分及其药代动力学研究
A reliable,rapid analytical method was established for characterization of constituents in rat blood sample after oral administration the extract of P.multiflorum by combining an ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS).And successfully identified 42 compounds which were absorbed through gastrointestine in rats.Moreover, the pharmacokinetic studies of some major compounds in blood were investigated by using ultra performance liquid romatography with tandem mass spectrometry (UPLC-MS/MSJ method. This study showed a comprehensive research of P. multiflorum, which could povide a meaningful basis for further quality control,pharmacological as well as toxicology researches.
何首乌提取物 血成分 药代动力学
Linlin Wang Mangmang Sang Erwei Liu Prince Osei Banahene Yi Zhang Tao Wang Lifeng Han Xiumei Gao
Tianjin State Key Laboratory of Modem Chinese Medicine, 312 Anshanxi Road,Nankai District, Tianjin, Tianjin State Key Laboratory of Modem Chinese Medicine, 312 Anshanxi Road,Nankai District, Tianjin,
国内会议
北京
中文
219-220
2016-09-21（万方平台首次上网日期，不代表论文的发表时间）