Transdermal delivery of compounds with different lipophilicity and molecular from water-in-oil microemulsions
The aim of this study was to explore the transdermal delivery potential of a new compound W/O microemulsion system.Permeation of different drugs from microemulsions was enhanced significantly compared with the extraction.Optimized batches were selected through construction of phase diagrams following stability studies.Globule size analyzed by zeta sizer of selected batches were found within the desired range (<200 nm).Selected microemulsion batches with acceptable viscosities, contained 5%, 8% and 10% of water content, for in-vitro skin penetration study using Franz-cells and excised rat skin.A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated in transdermal research.The drug permeation flux and the cumulative permeation amount of HSYA, Icariin and Gallic acid in the microemulsion batch ME-4 after 24 h increased significantly compared with extracting solution.Therefore, the microemulsion batch ME-4 was selected for future in vivo pharmacodynamics studies.
microemulsion Transdermal delivery LC-MS/MS Chinese compound formula Wenluotong (WLT)
Hongmei LIN Zhenzhen XIA Lingyan XU Qing WU
Department of TCM Pharmaceutics, School of Chinese Materia Medica, Beijing University of Chinese Medicine,Beijing, China
国内会议
桂林
英文
10-16
2016-11-18（万方平台首次上网日期，不代表论文的发表时间）