miR-663a inhibits hepatocellular carcinoma cell proliferation and invasion by targeting HMGA2
Hepatocellular carcinoma (HCC) is a highly aggressive solid malignancy throughout the world.Dysregulation of miRNAs play essential roles in HCC progression via aberrant regulation of cell proliferation, apoptosis, as well as metastasis, miR-663a is a poorly investigated miRNA.Whether miR-663a regulates HCC development remains unknown.The aim of the study was to explore the role of miR-663a in HCC development.To determine the expression level of miR-663a in HCC, we analyzed the data from GSE21362 and TCGA.The results showed that miR-663a was significantly down-regulated in HCC tissue compared with adjacent non-tumor tissue.Gain of function and loss of function assays revealed that miR-663a distinctly inhibited cell proliferation, migration and invasion.Mechanistic investigations demonstrated that miR-663a modulated cell functions through targeting and suppressing high mobility group A2 (HMGA2).In addition,overexpression of HMGA2 remarkably attenuated the tumor repressive effect of miR-663a.Taken together,miR-663a inhibits HCC cell proliferation and motility by targeting HMGA2.
hepatocellular carcinoma miR-663a HMGA2
袁霞 黄维甄
惠州市中心人民医院 516001
国内会议
广东省医学会肿瘤内科学分会成立大会暨广东省医学会第一次肿瘤内科学学术会议
广州
英文
151-159
2016-08-05（万方平台首次上网日期，不代表论文的发表时间）