Overexpression of TRIB3 promotes angiogenesis in human gastric cancer
Tribbles homolog 3 (TRIB3) plays important roles in many types of malignancies.However, whether TRIB3 is involved in the development or progression of gastric cancer (GC) remains unclear.In this study, we analyzed TRIB3 expression in GC tissues from 191 GC patients categorized with stage Ⅰ to Ⅳ disease, to examine the role of TRIB3 in GC, and examined the relationship between TRIB3 and tumor angiogenesis.We found that TRIB3 expression was significantly higher in GC tissues than that in adjacent non-tumor tissues.TRIB3 expression was associated with VEGF-A and tumor microvessel density, as well as overall TNM stage, T stage,N stage, and distant metastasis in GC tissues.Furthermore,TRIB3 silencing downregulated VEGF-A expression in GC cells, which subsequently suppressed endothelial cell recruitment and vessel formation.In conclusion, overexpression of TRIB3 is associated with tumor angiogenesis and a poor prognosis in patients with GC.Our findings indicate that TRIB3 is a promising target for anti-angiogenic therapy in GC.
angiogenesis gastric cancer tribbles homolog 3 VEGF-A
董少婷 夏建龄 王宏强 孙丽 吴珍珍 宾建平 廖禹林 廖旺军
南方医科大学南方医院肿瘤内科;惠州市中心人民医院 南方医科大学南方医院肿瘤内科 南方医科大学南方医院心内科
国内会议
广东省医学会肿瘤内科学分会成立大会暨广东省医学会第一次肿瘤内科学学术会议
广州
英文
253-262
2016-08-05（万方平台首次上网日期，不代表论文的发表时间）