The standard deviation of extracellular water/intracellular water is associated with all-cause mortality and technique failure in peritoneal dialysis patients
Purpose The mortality rate of peritoneal dialysis (PD)patients is still high, and the predicting factors for PD patient mortality remain to be determined.This study aimed to explore the relationship between the standard deviation (SD) of extracellular water/intracellular water (E/I) and all-cause mortality and technique failure in continuous ambulatory PD (CAPD) patients.Methods All 152 patients came from the PD Center between January 1 st 2006 and December 31 st 2007.Clinical data and at least five-visit E/I ratio defined by bioelectrical impedance analysis were collected.The patients were followed up till December 31st 2010.The primary outcomes were death from any cause and technique failure.Kaplan-Meier analysis and Cox proportional hazards models were used to identify risk factors for mortality and technique failure in CAPD patients.Results All patients were followed up for 59.6 ± 23.0 months.The patients were divided into two groups according to their SD of E/I values: lower SD of E/I group (≤0.126) and higher SD of E/I group (>0.126).The patients with higher SD of E/I showed a higher all-cause mortality (log-rank x2 =10.719, P =0.001)and technique failure (log-rank x2 =9.724, P =0.002)than those with lower SD of E/I.Cox regression analysis found that SD of E/I independently predicted all-cause mortality (HR 3.551, 95 % CI 1.442-8.746, P =0.006)and technique failure (HR 2.487, 95 % CI 1.093-5.659,P =0.030) in CAPD patients after adjustment for confounders except when sensitive C-reactive protein was added into the model.Conclusion The SD of E/I was a strong independent predictor of all-cause mortality and technique failure in CAPD patients.
Peritoneal dialysis Volume status Extracellular water Intracellular water Outcome
Jun-Ping Tian Hong Wang Feng-He Du Tao Wang
Department of Cardiology, Beijing Tian Tan Hospital, Capital Medical University, No.6, Tian Tan Xi L Department of Endocrinology, Aerospace Center Hospital,Beijing, People”s Republic of China Division of Nephrology, Peking University Third Hospital,49 North Garden Rd, Haidian District, Beiji
国内会议
北京
英文
183-190
2016-08-01（万方平台首次上网日期，不代表论文的发表时间）