Histological validation of frequency domain optical coherence tomography for the evaluation of neointimal formation after a novel polymer-free sirolimus-eluting stent implantation
Novel polymer-free drug-eluting stents have been developed to reduce polymer-related adverse events.However, neointimal coverage after polymer-free DES implantation is unclear and validation between optical coherence tomography (OCT) and histology is required.Sixteen polymer-free sirolimus-eluting stents were randomly implanted into coronary arteries of 8 normal swine.OCT and histological measurement were conducted at 3 or 6 months after stent placement.For quantitative measures, lumen area, stent area, neointimal area and neointimal thickness were validated in every single OCT and histology matched cross-section.Moreover, for qualitative analysis, OCT signal patterns of neointimal tissue were classified as homogeneous, layered and heterogeneous patterns based on optical intensity and backscatter pattern and peri-strut inflammation was also determined by histology.In total, 70 OCT and histology matched cross-sections were analyzed.At quantitative analysis, good correlations and agreements were found in the measurement of lumen area (ICC =0.67, P<0.001), neointimal area (ICC =0.89,P<0.001) and neointimal thickness (ICC =0.94, P<0.001) except for stent area (ICC 0.19, P =0.13) between OCT and histology.At qualitative analysis, lymphocyte infiltrations of peri-strut were more frequently seen in heterogeneous sections than in homogeneous sections (10/14 sections, 71.4% vs.12/50 sections, 24%;P =0.003).In conclusion, OCT has proper correlation and agreement with histology in assessment of neointimal formation and heterogeneous neointima assessed by OCT may also be associated with peri-strut inflammation detected in histology after polymer-free sirolimus-eluting stents implantation, supporting the use of OCT to evaluate neointimal coverage after polymer-free stent implantation in clinical practice.
Polymer-free optical coherence tomography histology neointima
Qiang Fu Hongyu Hu Wei Chen Zhixu Tan Li Li Dezhao Wang Buxing Chen
Department of Cardiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Pathology, National Center for Cardiovascular Disease, China and Fuwai Hospital, Chine
国内会议
北京
英文
197-204
2016-08-01（万方平台首次上网日期，不代表论文的发表时间）