Effect of tongxinluo on nephrin expression via inhibition of notch1/snail pathway in diabetic rats
Podocyte injury is an important mechanism of diabetic nephropathy (DN).Accumulating evidence suggests that nephrin expression is decreased in podocyte in DN.Moreover, it has been demonstrated that tongxinluo (TXL) can ameliorate renal structure disrupt and dysfunction in DN.However, the effect of TXL on podocyte injury in DN and its molecular mechanism is unclear.In order to explore the effect of TXL on podocyte injury and its molecular mechanism in DN, our vivo and vitro studies were performed.Our results showed that TXL increased nephrin expression in diabetic rats and in high glucose cultured podocyte.Meanwhile, TXL decreased ICN 1 (the intracellular domain of notch), HES 1 and snail expressionin podocyte in vivo and in vitro.More importantly, we found that TXL protected podocyte from injury in DN.The results demonstrated that TXL inhibited the activation of notchl/snail pathway and increased nephrin expression, which may be a mechanism of protecting effect on podocyte injury in DN.
Fangqiang Cui Dawei Zou Yanbin Gao Na Zhang Jinyang Wang Liping Xu Jianguo Geng Jiaoyang Li Shengnan Zhou Xinyao Wang
Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine,Ca Department of Endocrinology, Gansu Provincial People”s Hospital, 204 West Donggang Road, Lanzhou Cit
国内会议
北京
英文
198-213
2016-10-15（万方平台首次上网日期，不代表论文的发表时间）