Quercetin and Doxorubicin Co-encapsulated Biotin Receptor-targeting Nanoparticles for Minimizing Drug Resistance in Breast Cancer
The combination of a chemotherapeutic drug with a chemosensitizer has emerged as a promising strategy for cancers showing multidrug resistance(MDR).Herein we describe the simultaneous targeted delivery of two drugs to tumor cells by using biotin-decorated poly(ethylene glycol)-b-poly(ε-caprolactone)nanoparticles encapsulating the chemotherapeutic drug doxorubicin and the chemosensitizer quercetin(BNDQ).Next,the potential ability of BNDQ to reverse MDR in vitro and in vivo was investigated.Studies demonstrated that BNDQ was more effectively taken up with less efflux by doxorubicin-resistant MCF-7 breast cancer cells(MCF-7/ADR cells)than by the cells treated with the free drugs,single-drug–loaded nanoparticles,or non-biotin–decorated nanoparticles.BNDQ exhibited clear inhibition of both the activity and expression of P-glycoprotein in MCF-7/ADR cells.More importantly,it caused a significant reduction in doxorubicin resistance in MCF-7/ADR breast cancer cells both in vitro and in vivo,among all the groups.Overall,this study suggests that BNDQ has a potential role in the treatment of drug-resistant breast cancer.
biotin doxorubicin quercetin co-delivery multidrug resistance
Li Lv Chunxia Liu Chuxiong Chen Xiaoxia Yu Guanghui Chen Yonghui Shi Fengchao Qin Jiebin Ou Kaifeng Qiu Guocheng Li
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-Sen M Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation,Sun Yat-Sen M Department of Pharmacy,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,Guangdo
国内会议
广州
英文
1-27
2016-12-17（万方平台首次上网日期，不代表论文的发表时间）