Influence of Voriconazole on Pharmacokinetics and Safety of Combined drugs:A Systematic Review
We performed a systematic review to evaluate pharmacokinetics changes of drugs when concomitantly used with voriconazole(until Jan,2016).Among 41 studies included in our search,17 were randomized crossover trials,3 were RCTs,13 were self-controlled before-and-after study(SBAs),1 was cohort studies and 7 were case reports.A total of 12 classes of drugs were involved.According to our results,the impacts of voriconazole on tilidine,buprenorphine,etoricoxib,meloxicam,venlafaxine,midazolam,zolpidem,etravirine and sirolimus were different from the package insert.Our systematic review provided comprehensive data on the pharmacokinetics changes of drugs when used in combination with voriconazole.
Voriconazole Drug-drug interactions Pharmacokinetics
Yuanyuan Liu Shuyao Liang Ken Chen Fan Zhang Fang Liu
Department of pharmacy,Peking University Third Hospital,Beijing 100191 China;Department of pharmacy, Department of pharmacy,Peking University Third Hospital,Beijing 100191 China Department of pharmacy,The Second Hospital affiliated to XinJiang Medical University,Urumqi 830063 C
国内会议
北京
英文
1-27
2016-12-16（万方平台首次上网日期，不代表论文的发表时间）