Substructure-activity relationship studies on antibody recognition for phenylurea compounds using competitive immunoassay and computational chemistry

摘要：

Based on the structural features of fluometuron,an immunizing hapten was synthesized and conjugated to bovine serum albumin as an immunogen to prepare a polyclonal antibody.However,the resultant antibody indicated cross-reactivity with 6 structurally similar phenylurea herbicides,with binding activities (expressed by IC50 values) ranging from 1.67 μg/L to 42.71 μg/L.All 6 phenylurea herbicides contain a common moiety and three different substitutes.

作者: Fuyuan Zhang Bing Liu Guozhen Liu Yan Zhang Junping Wang Shuo Wang

作者单位: Key Laboratory of Food Nutrition and Safety,Ministry of Education of China,Tianjin University of Sci Key Laboratory of Food Nutrition and Safety,Ministry of Education of China,Tianjin University of Sci Department of Molecular Sciences,ARC Centre of Excellence in Nanoscale Biophotonics(CNBP),Macquarie Key Laboratory of Food Nutrition and Safety,Ministry of Education of China,Tianjin University of Sci

会议类型: 国内会议

会议名称: 第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018)

会议地点: 太原

会议语种:英文

页码: 324-331

在线出版日期: 2018-05-01（万方平台首次上网日期，不代表论文的发表时间）