Study of acylhydrazone derivatives with deoxygenated seven-membered rings as potential β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

摘要：

Fatty acid biosynthesis is essential for bacterial survival.FabH,β-ketoacyl-acyl carrier protein (ACP) synthase III,is a particularly attractive target,since it is central to the initiation of fatty acid biosynthesis and highly conserved among Gram-positive and Gram-negative bacteria.Following previous studies,a series of acylhydrazone derivatives with deoxygenated rings were synthesized in this work.

作者: Yang Zhou Yin Luo Yu-Shun Yang Liang Lu Hai-Liang Zhu

作者单位: State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210023,People”s Republic of China

会议类型: 国内会议

会议名称: 第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018)

会议地点: 太原

会议语种:英文

页码: 692-699

在线出版日期: 2018-05-01（万方平台首次上网日期，不代表论文的发表时间）