The health and production traits in bovine are associated with single nucleotide polymorphisms at NOD2 gene
NOD2 gene plays a fundamental role in the initiation of the inflammatory and subsequent immune response.Which have been previously identified as susceptibility loci for inflammatory bowel diseases in human.In this study,we detected two mutations in exon 12(A→T,G→A)among five cattle breeds(n=315)and analyzed their associations with production traits and genetic resistance against bovine mastitis in Chinese Holstein and Chinese Simmental breeds(n=218).The transitions(A→T)at position 114bp associated with SCS(p<0.01).The G→A at position 1594bp have been described to play a critical role to increase 305-day milk yields.In Chinese Holstein and Chinese Simmental breeds,BB genotype may contribute to disease susceptibility.When compared to all genotypic combinations,the genotypic combinations simultaneously carried allele A,B,and genotype FF are beneficial not only for reducing SCS but also increasing production.
NOD2 gene bovine mastitis SCS
W.Wang L.Chen J.Yi J.Gan H.Tang M.Z.Fu H.Wang S.J.Lai
College of Animal Science and Technology,Sichuan Agricultural University,Ya”an,Sichuan,China;Sichuan Sichuan animal husbandry station,Chengdu,Sichuan,China Sichuan Animal Science Academy,Chengdu,Sichuan,China College of Animal Science and Technology,Sichuan Agricultural University,Ya”an,Sichuan,China
国内会议
四川宣汉
英文
183-191
2016-09-27（万方平台首次上网日期，不代表论文的发表时间）