A Smart ”Midway Pickup” Drug Delivery System for Chemotherapy to Tumor Hypoxic Regions

摘要：

　　In this work,a novel drug delivery approach to enhance tumor penetration and accumulation via the midway pickup of therapeutic nanoparticles by tumor-associated macrophages(TAMs)en route toward tumor hypoxia was developed.The nanoparticle carriers equipped with high selective affinity with macrophages were first attained from the self-assembly of poly(lactic acid-co-glycolic acid)-grafted hyaluronic acid(HA-g-PLGA)together with an anticancer drug,SN38,in aqueous phase.

关键词： Midway pickup drug delivery sheddable polymeric shell polymeric nanoparticles chemotherapy tumor hypoxia

作者: Hsin-Cheng Chiu Chu-Wei Huang Wen-Chia Huang

作者单位: Department of Biomedical Engineering and Environmental Sciences,National Tsing Hua University,Hsinchu 30013,Taiwan,China

会议类型: 国内会议

会议名称: The 6th International Conference on Nanoscience and Technology, China 2015 (第六届中国国际纳米科学技术会议)

会议地点: 北京

会议语种:英文

页码: 99-100

在线出版日期: 2015-09-03（万方平台首次上网日期，不代表论文的发表时间）