The development of a quantitative and qualitative method based on UHPLC-QTOF MS/MS for evaluation paclitaxel-tetrandrine interaction and its application to a pharmacokinetic study

摘要：

Paclitaxel is a broad-spectrum anti-cancer drug by targeting microtubulin.However,multidrug resistant(MDR)makes its clinical application more difficult and results in failure of chemotherapy.Tetrandrine as a potential multidrug resistant modulator could be combined with other anti-cancer drugs.In this study,ultra-performance liquid chromatography(UHPLC)combined with quadrupole time-of-flight mass spectrometry(QTOF)was applied to simultaneously qualitative and quantitative analysis of paclitaxel for the pharmacokinetic studies while combined with tetrandrine.

关键词： UHPLC-QTOF MS/MS Paclitaxel Tetrandrine Surface plasmon resonance (SPR) Drug-drug interaction (DDI)

作者: Dan Li Zhonglian Cao Xueling Liao Ping Yang Li Liu

作者单位: School of Pharmacy,Fudan University,Shanghai,201203;Center for Pharmacological Evaluation and Resear School of Pharmacy,Fudan University,Shanghai,201203 Center for Pharmacological Evaluation and Research of SIPI,Shanghai Institute of Pharmaceutical Indu

会议类型: 国内会议

会议名称: 第21届全国色谱学术报告会

会议地点: 成都

会议语种:英文

页码: 386-387

在线出版日期: 2017-05-19（万方平台首次上网日期，不代表论文的发表时间）