Ultra High Sensitive Determine The Optical Impurities of Sitafloxacin by Capillary Electrophoresis with Cyclodextrin and Ligand-Exchange as Chiral Additives

摘要：

In this paper,a robust chiral separation method for the separation of four enantiomers of sitafloxacinwas developed.Method was developed with two kinds of chiral selectors including cyclodextrin andLigand-exchange as chiral additives.The method was optimized with the aid of response surfacemethodology (RSM) and Derringer”s desirability function.A central composite design was utilized tofulfill the design of experiments (DOE).

关键词： enantioseparation capillary electrophoresis stereoisomeric impurity experimental design

作者: Ranran Meng Jingwu Kang

作者单位: Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Lingling Road 345,Shanghai 200032,China

会议类型: 国内会议

会议名称: 第21届全国色谱学术报告会

会议地点: 成都

会议语种:英文

页码: 611-611

在线出版日期: 2017-05-19（万方平台首次上网日期，不代表论文的发表时间）