Design,synthesis,and antibacterial evaluation of new Schiff”s base derivatives bearing nitroimidazole and pyrazole nuclei as potent E.coli FabH inhibitors
New Schiff”s base derivatives 5a-j have been synthesized by reaction between 5-aryloxypyrazolc-4-carbaldchydes 3a-j and 2-(2-mcthyl-5-nitro-1H-imidazol-1-yl)acetohydrazide 4 in the presence of nickel(Ⅱ)nitrate as a catalyst in ethanol at room temperature with good yield(75-88%).All compounds were tested for antibacterial properties and inhibition of E.coli FabH.Of the compounds studied,the majority of the compounds showed effective antibacterial properties and inhibition of E.coli FabH activity.Compound 5i showed the most effective inhibition(IC50= 4.6 ± 0.2 μM)by binding into the active site of the E.coli FabH receptor with minimum binding energy(△Gb=-54.2961 kcal/mol).The binding was stabilized by two hydrogen bonds,two π-Π,and three π-cation interactions.
Pyrazole Imidazol Antibacterial activity E.coli FabH
Chetan B.Sangani Jigar A.Makwana Yong-Tao Duan Umesh P.Tarpada Yogesh S.Patel Ketan B.Patel Vivek N.Dave Hai-Liang Zhu
State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,People”s Repu Chemistry Department,Government Science College,Gandhinagar 382015,Gujarat,India
国内会议
大连
英文
244-256
2016-09-24（万方平台首次上网日期，不代表论文的发表时间）