Dihydropyrazoles containing morpholine:design,synthesis and bioassay testing as potent antimicrobial agents
A series of dihydropyrazole derivatives containing morpholine was designed and synthesized as antimicrobial agents.All of the synthesized compounds were characterized by 1H-NMR and MS.Afterwards they were evaluated for in vitro antibacterial activity against four bacteria strains.Along with S.aureus TyrRS inhibition and cytotoxicity examination,some compounds proved to be of low toxicity and potent,especially against Gram-positive bacteria strains.Compound 4s exhibited the potential to be new a antibacterial drug with strong broad-spectrum antimicrobial activity and enzyme inhibitory activity.Docking simulation was performed to position compound 4s into the S.aureus TyrRS structure active site to investigate the probable binding mode.A 3D-QSAR model was also established to explain how structural alterations affect the activity and guide further study.
Peng-Fei Wang Han-Yue Qiu Jun-Ting Ma Xiao-Qiang Yan Hai-Bin Gong Zhong-Chang Wang Hai-Liang Zhu
State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,P.R.China State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210093,P.R.China;Xuz
国内会议
大连
英文
269-277
2016-09-24（万方平台首次上网日期，不代表论文的发表时间）